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Cryo-EM analysis of a complex involving an Ex4 analog, the GLP-1R and G s heterotrimer revealed two receptor conformers with distinct modes of peptidereceptor engagement

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26 In the SURMOUNT-2 trial involving adults with type 2 diabetes, average weight loss over 72 weeks was approximately 13.4% (10 mg) and 15.7% (15 mg), compared to 3.3% for placebo